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D. Blaine Moore

Professor of Biology

PhD University of Florida; BS University of North Florida

Tel: 269-337-7301; Office: Dow 303

    Blaine Moore

2014-present   Professor of Biology, Kalamazoo College, MI
2007-2014   Associate Professor of Biology, Kalamazoo College, MI
2004-2007   Herbert H. and Grace A. Dow Assistant Professor of Biology, Kalamazoo College, MI
2001-2003   Assistant Professor of Biology, Kalamazoo College, MI
2000-2001   Visiting Assistant Professor of Biology, Haverford College, Haverford, PA
1998-2000   Postdoctoral Fellow, University of Pennsylvania School of Medicine, Philadelphia, PA


Research Interests
My general research focus is on the molecular and cell biology of neurons, particularly intrinsic and extrinsic factors regulating their survival and death. Two specific projects involving undergraduate collaborators are ongoing, one aimed at understanding the molecular basis for Alzheimer’s disease, and another investigating the molecular mechanisms of ethanol neurotoxicity.


BIOL 246 Cell and Molecular Biology with Lab
BIOL 350 Neurobiology with Lab
BIOL 460 Molecular Basis for Nervous System Disorders
BIOL 490 Functioning as a Biologist


Grants and Fellowships

2012-2013: PI on a grant from the Great Lakes Colleges Association New Directions Initiative: The subcellular mechanism of ethanol toxicity in human neurons. $11,000 + 3,500 institutional match.

2003-2006: Co-PI, along with Dr. James Langeland and Dr. Vivien Pybus of Kalamazoo College, on a grant from the Keck Foundation to fund the W.M. Keck Laboratory for Cellular and Molecular Analysis, $380,000.

2002-2005: PI on a grant from the National Science Foundation: MRI #0215896, Acquisition of a Phosphorimager to Investigate Phosphorylation and Regulation of TACE, $73,863.


Selected Publications
(* denotes Kalamazoo undergraduate coauthor)

Manyevitch, R, Protas, M, Scarpiello, S, Deliso, M Bass, B, Nanajian, A, Chang, M, Thompson, SM, Khoury, N, Gonnella, R, Trotz, M, Moore, DB, Harms, E, Perry, G, Clunes, L, Ortiz, A, Friedrich, JO, and Murray, IVJ (2018). Evaluation of metabolic and synaptic dysfunction hypotheses of Alzheimer’s disease (AD): a meta-analysis of CSF markers. Current Alzheimer Research 15(2):164-181.

Moore, DB, *Gillentine, MA, *Botezatu, NM, *Wilson, KA, *Benson AE and Langeland JA (2014) Asynchronous evolutionary origins of Aβ and BACE1.  Molecular Biology and Evolution. 31(3): 696-702.  doi:10.1093/molbev/mst262

Moore, DB (2013) editor, “Ethanol Neurotoxicity” special issue of Brain Sciences, Volume 3, issues 1-3. 

*Balan, AG, *Myers, BJ, *Maganti, J. and Moore, DB (2010) ER-targeted Bcl-2, and inhibition of ER-associated caspase-12, rescue cultured immortalized cells from ethanol toxicity. Alcohol, 44(6): 553-563.

Furge, LL, Stevens-Truss, R, Moore, DB, Langeland, J (2009) Vertical and horizontal integration of bioinformatics education: a modular, interdisciplinary approach. Biochemistry and Molecular Biology Education, 37 (1) Jan/Feb 24-55.

Moore, DB, Dueweke, A, Newton, CR, and Stevens-Truss R (2005) Mentoring students in professional-quality science communication. Council on Undergraduate Research Quarterly March, 2005: 118-121.

Moore, DB, Madorsky, I, Paiva, M, and Heaton, MB (2004) Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: effects of neonatal exposure. Journal of Neurobiology, 60(1):114-26.

Moore, DB, Madorsky, I, Paiva, M, and Heaton, MB (2004) Ethanol exposure alters neurotrophin receptor expression in the rat central nervous system: effects of prenatal exposure. Journal of Neurobiology, 60(1):101-13.

Heaton, MB, Moore, DB, Paiva, M, Madorsky, I, Mayer, J, Shaw, G (2003) The role of Neurotrophic factors, apoptosis-related proteins, and endogenous antioxidants in the differential temporal vulnerability of neonatal cerebellum to ethanol. Alcoholism Clinical and Experimental Research, 27 (4):657-669.

Heaton, MB, Paiva, M, Madorsky, I, Mayer, J, Moore, DB (2003) Effects of ethanol on neurotrophic factors, apoptosis-related proteins, endogenous antioxidants, and reactive oxygen species in neonatal striatum: relationship to periods of vulnerability. Developmental Brain Research, 140:237-252.

Moore, DB**, Skovronsky, DM**, (**equal contribution; Skovronsky listed first on publication), Milla, ME, Doms, RW, Lee, VMY (2000) PKC-Dependent a-secretase Competes with b-secretase for Cleavage of APP in the TGN. Journal of Biological Chemistry 275 (4):2568-2575.

Moore, DB, Walker, DW, Heaton, MB (1999) Neonatal ethanol exposure alters bcl-2 family mRNA levels in the rat cerebellar vermis. Alcoholism Clinical and Experimental Research 23 (7):1251-1261.

Heaton, MB, Moore, DB, Paiva, M, Gibbs, T, Bernard, O (1999): Bcl-2 overexpression protects the neonatal cerebellum from ethanol neurotoxicity. Brain Research 817:13-18.

Bradley, DM, Beaman, FD, Moore, DB, Kidd, K, Heaton, MB (1999) Neurotrophic factors BDNF and GDNF protect embryonic chick spinal cord motoneurons from ethanol neurotoxicity in vivo. Brain Research: Developmental Brain Research 112 (1):99-106.

Moore, DB, Quintero, M, Ruygrok, AC, Walker, DW, Heaton, MB (1998) Prenatal ethanol exposure reduces parvalbumin-immunoreactive GABAergic neuronal number in the adult rat cingulate cortex. Neuroscience Letters 249:25-28.