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Pittcon-2012

Refereed Publications

(undergraduate student co-authors are shown in bold)

Livezey, M., Nagy, L. D., Diffenderfer, L. E., Arthur, E. J., Hsi, D. J., Holton, J. M., Furge, L. L., (2012) Drug Metabolism Letters 6, 7-14. “Molecular Analysis and Modeling of Human CYP2D6 Inactivation by Four Mechanism-based Inactivators.”

Furge, L. L., Wolfson, A., Boyer, R. (2012) Biochem. Mol. Biol. Ed. 40, 23. “Commentary: Innovation in the Biochemistry/Molecular Biology Laboratory.”

Nagy, L. D., Mocny, C. S., Diffenderfer, L. E., Hsi, D. J., Butler, B. F., Arthur, E. J., Fletke, K. J., Palamanda, J. R., Nomeir, A. A., and Furge, L. L. (2011) Drug Metab. Dispos. 39, 974-83. “Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction.”

Furge, L. L. (2011) Biochem. Mol. Biol. Ed. 39, 87-90. “Institutional Review Boards and Education Research.”

Furge, L. L., Stevens-Truss, R., Moore, D. B., Langeland, J. (2009) Biochem. Mol. Biol. Ed. 37, 26-36. “Vertical and horizonal integration of bioinformatics education: a modular, interdisciplinary approach.”

Koeman, J. M., Russell, R. C., Tan, M.-H., Petillo, D., Westphal, M., Koelzer, K., Metcalf, J. L., Zhang, Z., Matsuda, D., Dykema, K. J., Houseman, H. L., Kort, E. J., Furge, L. L., Kohnoski, R. J., French Kidney Cancer Consortium, Swiatke, P. J., Teh, B. T., Ohh, M., Furge, K. A. (2008) PLoS Genetics 4, e1000176. “Somatic pairing of chromosome 19 in renal oncoytoma is associated with deregulated ELGN2-mediated oxygen-sensing response.”

Furge, L. L., Winter, M. B., Meyers, J. I., and Furge, K. A. (2008) Biochem. Mol. Biol. Ed. 36, 149-152. “Experimental Approaches to Microarray Analysis of Tumor Samples.”

Furge, L. L. and Fletke, K. J. (2007) Biochem. Mol. Biol. Ed. 35, 138-144. "HPLC Determination of Caffeine and Paraxanthine in Urine: An Assay for Cytochrome P450 1A2 Activity."

Konwinski, R. R., Haddad, R., Chun, J.A., Klenow, S., Larson, S., Haab, B. B., Furge, L. L. (2004) Toxicol. Lett. 153, 343-355 "Oltipraz, 3H-1,2-dithiole-3-thione, and Sulforaphane Induce Antioxidant Responses in Microglial Cells."

Furge, L. L., Fields, P. R., Goode, W. E., Konwinski, R. R., Tressler, M. C., and Stevens-Truss, R. (2004) Arch. Biochem. Biophys. 424, 163-170 "Oltipraz Inhibits Inducible Nitric Oxide Synthase in vitro and Inhibits Nitric Oxide Production in Activated Microglial Cells."

Langouët, S., Furge, L. L., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F. P. (2000) Chem. Res. Toxicol. 13, 245-252. "Inhibition of Human Cytochrome P450 Enzymes by 1,2-Dithiole-3-thione, Oltipraz and Its Derivatives, and Sulforaphane."

Furge, L. L., Chen, K., and Cohen, S. (1999) J. Biol. Chem. 274, 33504-33509. "Annexin VII and Annexin XI are Tyrosine-phosphorylated in Peroxovanadate-Treated Dogs and in Platelet-derived Growth Factor-treated Rat Vascular Smooth Muscle Cells."

Furge, L. L. and Guengerich, F. P. (1999) Biochemistry, 38, 4818-4825. "Explanation of Pre-Steady-State Kinetics and Decreased Burst Amplitude of HIV-1 Reverse Transcriptase at Modified DNA Bases with an Additional, Non-Productive Enzyme-DNA-Nucleotide Complex."

Furge, L. L. and Guengerich, F. P. (1998) Biochemistry 37, 3576-3574. "Pre-steady-state Kinetics of Nucleotide Insertion Following 8-Oxo-7,8-dihydroguanine Base Pair Mismatches by Bacteriophage T7 DNA Polymerase exo-."

Furge, L. L. and Guengerich, F. P. (1997) Biochemistry 36, 6475-6487. "Analysis of Nucleotide Insertion and Extension at 8-Oxo-7,8-dihydroguanine by Replicative T7 Polymerase exo- and Human Immunodeficiency Virus-1 Reverse Transcriptase Using Steady-State and Pre-Steady-State Kinetics."

Lowe, L. G. and Guengerich, F. P. (1996) Biochemistry 35, 9840-9849. "Steady-State and Pre-steady State Kinetic Analysis of dNTP Insertion Opposite 8-Oxo-7,8-dihydroguanine by Escherichia coli Polymerases I exo- and II exo-."

Byrne, M. P., Manuel, R. L., Lowe, L. G., and Stites, W. E. (1995) Biochemistry 34, 13949-13960. "Energetic Contribution of Side Chain Hydrogen Bonding to the Stability of Staphylococcal Nuclease."

 

Invited Reviews

Furge, L. L. and Guengerich, F. P. (2006) Biochemistry and Molecular Biology Education 34, 66-74. "Cytochrome P450 Enzymes in Drug Metabolism and Chemical Toxicology: An Introduction."

Guengerich, F. P., Kim, M.-S., Muller, M., and Lowe, L.G. (1996) Proceedings, 4th Sonderforschungsbereich Int. Sympos. (25-27 May, Wurzburg, Germany). "Chemical Mechanisms of Formation of DNA-Carcinogen Adducts, Elucidation of Potential of Adducts for Mutagenicity, and Mechanisms of Polymerase Fidelity and Mutation in the Presence of Adducts."

 

Book Reviews

Furge, L. L. (2011) Biochemistry and Molecular Biology Education 39, 469. “Book Review: Water and Life: The Unique Properties of H2O. Edited by Ruth M. Lynden-Bell, Simon Conway Morris, John D. Barrow, John L. Finney, and Charles L. Harper, Jr.”

Furge, L. L. (2010) Biochemistry and Molecular Biology Education 38, 434. “Book Review: Giant Molecules: From Nylon to Nanotubes, by Walter Gratzer.” 

Furge, L. L. (2009) Biochemistry and Molecular Biology Education 37, 133-134. “Book Review: Essentials of Chemical Biology: Structure and Dynamics of Biological Macromolecules, by Andrew Miller and Julian Tanner.” 

Furge, L. L. (2008) Biochemistry and Molecular Biology Education 36, 385. “Book Review: Biochemistry of Signal Transduction and Regulation, 4th Edition, by Gerhard Kraus.”

 

Other Reviewed Publications

Furge, L. L. (Nov. 13, 2006) Chemical & Engineering News 84, 5-9 “Letters: Study-abroad Programs.”

Furge, L. L. (Oct. 3, 2008) Science. “E-Letters: Assessing Drug Metabolism.” http://www.sciencemag.org/content/320/5872/53/reply#sci_el_11327?sid=a6780984-a9e9-449e-9095-00d199f14e4f.

Furge, L. L. (Oct. 19, 2009) Chemical & Engineering News  87, 4-5. “Letters: Skip the Stereotypes.”

 

Abstracts

(undergraduate student co-authors are shown in bold)

Livezey, M.R., Nagy, L. D., Diffenderfer, L. E., Arthur, E. J., Hsi, D.J., Furge, L. L. (2012) Great Lakes Drug Metabolism Discussion Group (3-4 May, Kalamazoo, MI). “Molecular Analysis and Modeling of Inactivation of CYP2D6 by Four Mechanism-based Inhibitors.”

Bolles, A., Livezey, M.R., Nagy, L. D., Briggs, E.D., Furge, L. L. (2012) Great Lakes Drug Metabolism Discussion Group (3-4 May, Kalamazoo, MI). “The Effect of Metoclopramide Metabolism on CYP2D6.”

Hicks, M., Nagy, L. D., Diffenderfer, L. E., Mocny, C. S., Arthur, E. J., Hsi, D.J., Furge, L. L. (2012) Great Lakes Drug Metabolism Discussion Group (3-4 May, Kalamazoo, MI). “Covalent Modification of CYP2D6 by SCH66712 at Thr309.”

Livezey, M.R., Nagy, L. D., Diffenderfer, L. E., Arthur, E. J., Hsi, D.J., Furge, L. L. (2012) American Society for Biochemistry and Molecular Biology Meeting (21-25 April, San Diego, CA). “Molecular Analysis and Modeling of Inactivation of CYP2D6 by Four Mechanism-based Inhibitors.”

Furge, L. L. (2011) American Society for Biochemistry and Molecular Biology Special Conference: Student Centered Education in the Molecular Life Sciences (20-23 July, Richmond, VA). “A Few of My Favorite Things: Critical Thinking Exam Questions that Use Bloom’s Taxonomy.”

Diffenderfer, L. E., Hsi, D.J., Arthur, E. J., Furge, L. L. (2011) American Society for Biochemistry and Molecular Biology Meeting (9-13 April, Washington, DC). “Use of AutoDock to Understand Inactivation of Human Cytochrome P450 2D6 by SCH 66712.”

Nagy, L. D., Mocny, C. S., Hsi, D.J., Diffenderfer, L. E., Butler, B. F., Arthur, E. J., Fletke, K. J., Palamanda, J. R., Guengerich, F. P., Nomeir, A. A., Furge, L. L. (2011) American Society for Biochemistry and Molecular Biology Meeting (9-13 April, Washington, DC). “Mechanism-Based Inhibition of Human Cytochrome P450 2D6 by Schering 66712 Involves Protein Adduction.”

Diffenderfer, L. E., Hsi, D.J., Arthur, E. J., Furge, L. L. (2010) West Michigan Regional Undergraduate Science Conference (30 October, 2010, Grand Rapids, MI). “AutoDock as a Method for Predicing Binding for Substrates and Inhibitors of Human Cytochrome P450 2D6 and 2C9.”

Nagy, L. D., Mocny, C. S., Hsi, D.J., Arthur, E. J., Butler, B. F., Diffenderfer, L. E., Palamanda, J. R., Guengerich, F. P., Nomeir, A. A., Furge, L. L. (2010) West Michigan Regional Undergraduate Science Conference (30 October, 2010, Grand Rapids, MI). “Mechanism-Based Inhibition of Human Cytochrome P450 2D6 by Schering 66712.”

Mocny, C. S
., Arthur, E. J., Butler, B. F., Diffenderfer, L. E., Palamanda, J. R., Guengerich, F. P., Nomeir, A. A., Furge, L. L. (2010) American Society for Biochemistry and Molecular Biology Meeting (24-28  April, 2010, Anaheim, CA). “Mechanism-Based Inhibition of Human Cytochrome P450 2D6 by Schering 66712.”

Mocny, C. S., Arthur, E. J., Butler, B. F., Diffenderfer, L. E., Hsi, D., Nagy, L. D. Palamanda, J. R., Guengerich, F. P., Nomeir, A. A., Furge, L. L. (2010) Michigan State Univeristy-Kalamazoo Center for Medical Sciences Research Day (14  April, 2010, Kalamazoo, MI). “Mechanism-Based Inactivation of Human Cytochrome P450 2D6 by a Piperazine-containing Compound.”

Furge, L. L. (2009) American Society for Biochemistry and Molecular Biology Meeting 18-22 April, 2009, New Orleans, LA). “Performance Tasks as Active-Learning Tools for Non-science Majors.”

Furge, L. L. (2008) American Society for Biochemistry and Molecular Biology Meeting (5-9 April, 2008, San Diego, CA). "Infusion of Bioinformatics into Biochemistry Curriculum at Kalamazoo College."

Furge, L. L. (2007) Enriching the Academic Experience of College Science Students Conference (22-24 May 2007, Ann Arbor, MI). "Making Believers and Re-establishing Interest - Engaging Non-science Majors in the Sciences."

Fletke, K. J., Furge, L. L. (2007) American Society for Biochemistry and Molecular Biology Meeting (28 April 28 - 2 May, 2007, Washington, D. C.). "Phenotyping Cytochrome P450 1A2 in Humans: Concepts in Drug Metabolism, Individualized Medicine, and Bioethics."

Butler, B. F., Palamananda, J., Nomeir, A. A., Guengerich, F. P., Furge, L. L. (2007) American Society for Biochemistry and Molecular Biology Meeting (28 April 28 - 2 May, 2007, Washington, D. C.). "Inhibition of Human Cytochrome P450 2D6 by Schering 66712."

Furge, L. L., Palamanda, J.R., Nomeir, A.A., Guengerich, F.P. (2006) Inaugural Meeting of the Great Lakes Drug Metabolism Discussion Group (27-28 April, 2006, Augusta, MI). "Mechanism-based Inhibition of Human Cytochrome P450 2D6 by Schering 66712."

Furge, L. L. (2006) American Society for Biochemistry and Molecular Biology Meeting (1-6 April, San Francisco, CA). "Toxicology and Carciongenesis: A Course to Interest Science and Non-Science Majors"

Furge, L. L., and Fieg, A.. (2004) American Chemical Society National Meeting (21-25 August, Philadelphia, PA). Invited Speaker for Symposium in chemical Education: "Teaching Bioinformatics in the Undergraduate Curriculum." Title of Presentation: "Integrating Bioinformatics into Existing Biochemistry Courses: Need, Implementation, and Student Reaction."

Furge, L. L., Konwinski, R. R., Chun, J. A., Haddad, R., Klenow, S., Larson, S. C., Haab, B. B. (2004) American Chemical Society National Meeting (21-25 August, Philadelphia, PA). "Activation of an Antioxidant Response by Oltipraz, 3H-1,2-Dithiole-3-thione, and Sulforaphane in Murine Microglial Cells."

Stevens-Truss, R., Fields, P. R., Goode, W. E., Tressler, M. C., and Furge, L. L. (2003) 14th International Union of Biochemistry and Molecular Biology Congress (20-24 July, Toronto, Canada). "Inhibition of Inducible Nitric Oxide Synthase Activity by Oltipraz in vitro and in Activated Microglial Cells." (meeting cancelled and rescheduled due to SARS)

Furge, L. L., Fields, P. R., Goode, W. E., Tressler, M. C., and Stevens-Truss, R. (2003) 13th International Conference on Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology (29 June - 3 July, Prague, Czech Republic). "Inhibition of Inducible Nitric Oxide Synthase Activity by Oltipraz in vitro and in Activated Microglial Cells."

Furge, L. L., Palamanda, J.R., Nomeir, A.A., Guengerich, F.P. (2001) 12th International Conference on Cytochrome P450: Biochemistry, Biophysics, and Molecular Biology (11-15 September, La Grande Motte, France). "Mechanism-based Inhibition of Human Cytochrome P450 2D6 by Schering 66712."

Furge, L. L. (2001) 33rd Great Lakes/Central Regional Meeting of the American Chemical Society (11-13 June, Grand Rapids, MI). "Biochemistry Research at an Undergraduate Institution: A New Faculty Member's Perspective." *Furge, L. L., Langouët, S., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F.P. (2000) International Conference on Mechanisms of Antimutagenesis and Anticarcinogenesis (23-27 September, Grand Rapids, MI). "Inhibition of Human Cytochrome P450 1A2 Enzyme by Oltipraz."

Furge, L. L., Langouët, S., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F.P. (2000) Cancer and Molecular Genetics in the Twenty-first Century (5-8 September, Grand Rapids, MI). "Inhibition of Human Cytochrome P450 1A2 Enzyme by the Chemopreventive Agent Oltipraz."

Furge, L. L., Chen, K., and Cohen, S. (2000) Thirteenth Annual Chicago Signal Transduction Symposium (25 May, Chicago, IL). "Tyrosine-phosphorylation of Annexin VII, Annexin XI, Clathrin Heavy Chain, and Ezrin in response to Peroxovanadate and Platelet-derived Growth Factor-BB."

Langouët, S. Furge, L.L., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F.P., (2000) Abstracts, 220th Am. Chem. Soc. Natl. Meeting. (26-31 March, San Francisco) No. TOXI 86. "Mechanism-based Inactivation of Human Cytochrome P450 1A2 by Oltipraz."

Langouët, S., Furge, L. L., Kerriguy, N., Nakamura, K., Guillouzo, A., and Guengerich, F. P. (2000) Proc. Am. Assoc. Cancer Res. 41, 662. "Inhibition of Human Cytochrome P450 Enzymes by Oltipraz."

Furge, L. L., Chen, K., and Cohen, S. (1999) Thirteenth Symposium of the Protein Society (24-28 July, Boston, MA). "Annexin VII, Annexin XI, Ezrin, and Clathrin are Tyrosine-phosphorylated in Liver and Kidney of Peroxovanadate-treated Dog."

Guengerich, F. P., Furge, L. L., Einolf, H.J., Mican, A. N., Kim, M.-S., Langouët, S., and Müller, M. (1998) Fifth International Meeting, International Society for the Study of Xenobiotics (25-29 Oct., Cairns, Australia). "DNA adducts and mechanism of mutagenesis."

Furge, L. L., and Guengerich, F. P. (1998) Molecular Biology and Pathology of Neoplasia Conference (12-19 July, Keystone, CO). "Stopped-Flow Pre-Steady-State Kinetics of Nucleotide Addition Opposite 8-Oxo-7,8-dihydroguanine by DNA Polymerases. "

Furge, L. L. and Guengerich, F. P. (1998) Proc. Am. Assoc. Cancer Res. 39, 647-648. "Pre-steady-state Kinetics of Preferential Extension of the 8-Oxo-7,8-dihydroguanine:Adenine Base Pair Mismatch by T7 DNA Polymerase exo-."

Lowe, L. G., Einolf, H. J., and Guengerich, F. P. (1997) Proc. Am. Assoc. Cancer Res. 38, 41-42. "Kinetics of Deoxyribonucleotide Insertion and Extension at 8-Oxo-7,8-dihydroguanine by T7 Polymerase exo- and HIV-1 Reverse Transcriptase."

Guengerich, F. P., Lowe, L. G., and Langouët, S. (1997) 15th Winter Enzyme Mechanisms Conference (4-8 Jan., Naples, FL). "Pre-steady-state kinetic analysis of polymerase misincorporation of dNTPs at sites of DNA-carcinogen adducts."

Lowe, L. G. and Guengerich, F. P. (1996) The Univ. of Ark. for Medical Sciences Arkansas Toxicology Symposium (9-11 Oct., Little Rock, AR). "Kinetics of Deoxyribonucleotide Insertion and Extension of 8-Oxo-7,8-dihydroguanine by Escherichia coli Polymerases I and II exo-, T7 Polymerase exo-, and HIV-1 Reverse Transcriptase."

Lowe, L. G. and Guengerich, F. P. (1996) Proc. Am. Assoc. Cancer Res. 37, 961. "Single-turnover Kinetic Analysis of Escherichia coli Pol I exo- and Pol II exo- Fidelity During DNA replication of 8-Oxo-7,8-dihydroguanine."

Lowe, L. G. and Guengerich, F. P. (1995) Natl. Inst. Environ. Health Sci. Fidelity in DNA Replication Conference (10-14 Sept., Wrightsville Beach, NC). "Single-turnover Kinetic Analysis of Deoxyribonucleotide Misinsertion Opposite 8-Oxo-dihydroguanine by Escherichia coli Polymerase I exo- and Polymerase II exo-."

Lowe, L. G., Anderson, W. F., and Guengerich, F. P. (1995) Proc. Am. Assoc. Cancer Res. 36, 155. "Misinsertion of Deoxyribonucleotides at the Sites of Modified Guanine Residues by Escherichia coli Polymerase II exo-."