Professor of Chemistry Laura Furge has received a renewal of her National Institutes of Health (NIH) grant to support continued research in the area of drug-drug interactions. She will conduct this research with undergraduate science students at Kalamazoo College. Adverse drug-drug interactions are common among individuals who take multiple drugs (both over the counter and prescribed), particularly among older persons and among individuals whose bodies express variants of drug metabolizing (drug processing) enzymes. The research in the Furge lab will benefit human health by adding to the understanding of how certain classes of drugs may interact in individuals and cause drug-drug induced unfavorable medical events. Furge currently has five research students working in her lab and has mentored two dozen in her lab and many more in her classes over the past 13 years at K. Funding from the NIH will help ensure continued research opportunities for future generations of scientists. The grant will provide $225,000 over three years.
[bells recycle poster 2012]
Bell’s Eccentric Café was the venue for an American Chemistry Society local gathering on the evening of Dec. 4, 2012. Three Chemistry majors – Josh Abbott (K’13, chair of the College’s ACS student affiliate) along with Mara Livezey (K’13) and Amanda Bolles (K’14) joined the event titled, “Sustainable Science – Recycle a Poster.” Students presented posters they “recycled” from other conferences this fall. The keynote address, “Scientific Influences on the Ancient Art of Brewing (and Drinking) Beer”, was given by Bell’s Production Manager John Mallett. Beer sampling (for those over 21!) followed. The event was attended by ~50 local chemistry professionals, undergraduate and graduate students poster presenters, and Pfizer employees.
Erik Guetschow (K '10) received the 2011-2012 Florence Fenwick Outstanding Graduate Student Instructor Award at the University of Michigan for contribution to innovation in the lab or classroom in undergraduate courses.
Professor Jennifer Furchak and collaborators have recently published a paper, Detection of prolactin inducible protein mRNA, a biomarker for breast cancer metastasis, using a molecular beacon-based assay, in Analytical and Bioanalytical Chemistry, Volume 404, 2012, pp. 399-406. Coauthors include Erik D. Guetschow (K '10); Will Black (K '10); Carolyn M. Walsh (K '10); and Jennifer R. W. Furchak.
Chemistry majors Sandrine Zilikana (K ’12) and Mara Livezey (K [Zilikana ASBMB 2012]’13) and biology major Lindsey Gaston (K ’12) joined chemistry department faculty members Regina Stevens-Truss and Laura Lowe Furge at the American Society for Biochemistry and Molecular Biology Meeting in San Diego in late April. The students presented results of their summer research experiences (part of the Senior Individualized Projects for Sandrine and Lindsey) as part of both the Annual Undergraduate Poster Competition and the regular scientific sessions of the meeting. More than 200 students from schools across the country were part of the undergraduate [Livezey ASBMB 2012]poster competition.[Gaston ASBMB 2012]
Professor Laura Furge and collaborators have recently published a paper, Molecular Analysis and Modeling of Inactivation of Human CYP2D6 by Four Mechanism Based Inactivators, in Drug Metabolism Letters, Volume 6, Number 1, March 2012, pp. 7-14(8). Coauthors include Mara Livezey (K '13); Leslie D. Nagy (K '09); Laura E. Diffenderfer (K '11); Evan J. Arthur (K '09); David J. Hsi (K '10); Jeffrey M. Holton (K '13); and Laura Lowe Furge.
Six senior science majors (five in biology, one in chemistry) attended the West Michigan Regional [VanAndel crew]Undergraduate Science Research Conference at the Van Andel Institute (Grand Rapids, Mich.). Five of the six were among 143 undergraduate students from several colleges and universities in the region who presented posters. The students also attended several interesting research talks by prominent scientists. The six were joined by professors Regina Stevens-Truss (chemistry) and Ann Fraser (biology). The “K” students presented work conducted as part of their Senior Individualized Project research. Attendees included (l-r): Alex Münch (K '12), biology; Molly Waytes (K '12), biology presenter; Sandrine Zilikana (K '12), chemistry presenter; Elizabeth Karslake (K '12), biology presenter; Lindsey Gaston (K '12), biology presenter; Sarvenaz Bagheri (K '12), biology presenter; Regina Stevens-Truss, and Ann Fraser.
Undergraduate Research Week 2012 is April 16-20. Kalamazoo College has several events to highlight and celebrate the research work done by our math and natural sciences students, especially those who have finished a Senior Individualized Projects (SIP). Seniors will present their work at the Robert C. Kelly SIP Symposium (Chemistry, April 13-14), the SIP Fest (Physics, Math, Computer Science, and Complex Systems, April 18), and the Diebold Symposium (Biology, April 26-28). A poster session for science students who have presented their research results at national scientific meetings will occur on Thursday, April 19. Kalamazoo students have participated in national meetings of the American Chemical Society, Pittsburgh Conference on Analytical Chemistry, the Western Spectroscopy Association, and The American Society for Biochemistry and Molecular Biology.
Dr Regina Stevens-Truss, as part of a team from the American Society for Biochemistry and Molecular Biology, was awarded a grant from the National Science Foundation to lead a workshop to enhance STEM education in middle and high schools. The workshop, Hands-on Opportunities to Promote Engagement in Science (HOPES), which took place in April 2011, had three goals. First, it aimed to remove one of the barriers – not knowing one another – that prevents collaboration between teachers and scientists. Second, it aimed to give participants examples of successful partnerships as potential models for collaborative efforts. And, third, it offered NSF funds, in the form of seed grants, for 10 teachers to encourage and support the development of partnerships and classroom activities.
[Pittcon 2012]Lydia Manger (K '13), Vinay Sharma (K '12), and Professor Jennifer Furchak attended the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy in Orlando in March 2012 where Lydia presented her research in a poster session on Bioanalytical Capillary Electrophoresis, Vinay presented his research in a poster session on Fluorescence and Luminescence, and Professor Furchak presented the group's research in an oral session on Bioanalytical Assays and Sensors.
Professor Jeffrey Bartz and collaborators have recently published a paper, A method for the determination of speed-dependent semi-classical vector correlations from sliced image anisotropies, in the Journal of Chemical Physics, 135, 094201 (2011). Coauthors include Michael P. Grubb, Michelle L. Warter, C. Daniel Freeman, Niclas A. West (K '12), Kelly M. Usakoski (K '13), Kurt M. Johnson, Jeffrey A. Bartz, and Simon W. North.
Hashem Akhavan-Tafti (K '82) has been awarded the Edwin F. Ullman Award for 2011 by the American Association for Clinical Chemistry. The award recognizes an individual (or individuals) for contributions to the field of clinical chemistry through the creation of new technologies or analytical methods, or through significant adaptations for application to clinical laboratory diagnostics of technologies from other fields.
Professor Jennifer Furchak has received a 2011 Cottrell College Science Award from the Research Corporation for Science Advancement. She will use the $35,000 award to further her work into the development of a multiplexed assay for the analysis of breast cancer metastasis. Five undergraduate researchers at K have worked on this project thus far. It’s been the foundation for three completed Senior Independent Projects, and another is in progress this summer. Furchak’s grant is one of 48 Cottrell grants this year totaling $1.8 million and intended to support early career scientists at liberal arts colleges and primarily undergraduate universities. Undergraduate students must be involved in the research in meaningful ways. Founded in 1912, Research Corporation for Science Advancement is the second-oldest foundation in the United States and the oldest foundation for science advancement.
Laura Diffenderfer (K ’11), Alyssa McNamara (K ’11), Leslie Nagy (K ’09), Tanav Popli (K '11), and Professor Laura Furge attended the April 2011 American Society for Biochemistry and Molecular Biology Meeting in Washington, DC.
[ASBMB 2011]Laura Diffenderfer (K ’11) presented a poster titled Autodock as a method for predicting binding for substrates and inhibitors of human cytochrome [ASBMB 2011]P450 2D6.
Alyssa McNamara (K ’11) presented a poster titled Suramin discriminates between the calmodulin-binding sites of neuronal and inducible nitric oxide synthase.
[ASBMB 2011]Leslie Nagy (K ’09) presented a poster titled Mechanism-based inhibition of human cytochrome P450 2D6 by Schering 66712.[ASBMB 2011]
Tanav Popli (K '11) presented a poster titled Tmtc4 interacts with C3G, Wntless, and Zfhx4: a yeast two-hybrid trap for proteins associated with development of the corpus callosum.
Professor Laura Furge and collaborators have recently published a paper, Substituted Imidazole of 5-Fluoro-2-[4-[(2-phenyl-1H-imidazol-5-yl)methyl]-1-piperazinyl]pyrimidine Inactivates Cytochrome P450 2D6 by Protein Adduction, in Drug Metabolism and Disposition. Leslie D. Nagy (K '09), Catherine S. Mocny (K '10), Laura E. Diffenderfer (K '11), David J. Hsi (K '10), Brendan F. Butler (K '07), Evan J. Arthur (K '09), Kyle J. Fletke (K '07), Jairam R. Palamanda, Amin A. Nomeir, and Laura Furge, Drug Metabolism and Disposition. DMD Fast Forward.
The American Society for Biochemistry and Molecular Biology (ASBMB) was awarded $24,500 by the National Science Foundation to embark on a project to foster outreach, educational and career development partnerships between biochemistry and molecular biology faculty and junior high school teachers in the Washington, D.C. area. The money will be used to provide teachers with seed grants to assist them and their college/university partners in developing and incorporating hands-on activities in classrooms that will directly impact students’ learning. The ultimate goal of this project is to establish ongoing dialogues between science teachers from D.C. metro area school districts and teaching faculty and researchers, in an effort to improve the quality of K-12 science education. The workshop was co-hosted by the ASBMB Minority Affairs (MAC) and the Educational and Professional Development (EPD) committees at the April 2011 meeting of the ASBMB. The principle investigators for this project are Peter J. Kennelly, Virginia Tech University; Regina Stevens-Truss, Kalamazoo College; Ishara Mills-Henry, Harvard University and Carla Mattos, North Carolina State University.
[Lydia Manger Pittcon 2011]
Lydia Manger (K '13), Amy Ong (K '11), and Professor Jennifer Furchak[Amy Ong Pittcon 2011] attended the Pittsburgh Conference on Analytical Chemistry and Applied Spectroscopy in Atlanta in March 2011 where Lydia presented her research in a poster session on Capillary Electrophoresis Applications, Amy presented her research in a poster session on Fluorescence/Luminescence in Bioanalytical and Materials Applications, and Professor Furchak presented the group's research in an oral session on Fluorescence/Luminescence in Bioanalytical and General Applications.
On October 6, 2010, Dr. Michael Summers, Professor of Chemistry and Biochemistry at the University of Maryland, Baltimore County, presented "New Insights into the Mechanism of HIV-1 Assembly in Infected Cells" for the Kalamazoo College 2010 Howard Hughes Medical Institute Guest Scholar Lecture.
Amber (Terry) Hupp (K ’03) has been hired as an assistant professor of chemistry, a tenure track position, at College of the Holy Cross in Worcester, Massachusetts. She focuses her teaching and research on analytical chemistry. Amber was a visiting assistant professor at Holy Cross in 2009-10. She earned her B.A. in chemistry from “K” and Ph.D. in analytical chemistry from Michigan State University.
Professor Regina Stevens-Truss has been named the Kurt D. Kaufman Chair--established by the late Trustee Paul Todd to honor Dr. Kurt Kaufman, Professor of Chemistry, in light of his significant leadership and wide influence as a faculty member at Kalamazoo College. It is awarded to a faculty member at the College to "recognize and honor campus leadership and excellence in teaching."
Professor Jennifer Furchak has been named the Herbert H. and Grace A. Dow Assistant Professor of Chemistry for 2010 through 2013--given for her solid teaching, service within the department and the College, and for her effectiveness in engaging students in her scholarly work.
Dr. Jeff Bartz and two students gave talks at the 65th International Symposium on Molecular Spectroscopy, The Ohio State University, Columbus, Ohio, June 24, 2010.
Niclas A. West (K '12) talked on his Summer 2009 research: “Velocity-Mapped Ion Imaging of Methyl Nitrite Photodissocation.” Aidan J. Klobuchar (K '12) spoke right after Nic about his work in Summer 2009 and Spring 2010: “Photodissociation of Methyl Nitrite from the S2 State – Ion Images and Vector Correlations.” Dr. Jeff Bartz talked about the work of Amber Peden (K '11) and Ryan Kieda (K '09): “Vector Correlation in the Photodissociation of Metal Nitrosyls.”
Professor Greg Slough and collaborators have recently published a paper, Synthesis of Quinazolines from N-(2-Nitrophenylsulfonyl)iminodiacetate and α-(2-Nitrophenylsulfonyl)amino Ketones via 2H-Indazole 1-Oxides, in the Journal of Organic Chemistry. Křupková, S.; Slough, G. A.; Krchňák, V. The Journal of Organic Chemistry. Article ASAP, Publication Date (Web): June 4, 2010.
Professor Jeffrey Bartz and collaborators have recently published a paper, Determination of the v-j vector correlation in the photodissociation of nitrosobenzene at 305 nm, in the Journal of Chemical Physics. Jeffrey A. Bartz, Stephanie C. Everhart, and Joseph I. Cline, J. Chem. Phys. 132, 074310 (2010).
[Tourtellotte Lecture 2010]
On April 5, 2010, Dr. Eric Kool, the George and Hilda Daubert Professor of Chemistry at Stanford University, presented "Mimicking Biological Functions with DNA Base Replacements: Synthesis, Applications, and Cellular Activity" for the Kalamazoo College 2010 Tourtellotte Lecture.
Aubrey Ann Parker (K '08) is pursuing a B.S.E. in chemical engineering at the University of Michigan and is one of 12 students from the University of Michigan who attended the United Nations Climate Change Conference in Copenhagen, Denmark from December 8-17, 2009. While she was there, she blogged for the Detroit Free Press. Aubrey traveled to Patagonia, Chile as a Graham Institute Scholar in 2009, where she studied relationships between hydroelectric development projects and aquatic ecosystems.
[Western Spectroscopy 2009]Amber Peden (K '11) presented a poster at the 56th Annual Western Spectroscopy Association, January 28 – 30, 2009, at the Asilomar Conference Center, Pacific Grove, CA. Her poster, Velocity Distribution in the Photodissociation of CpNiNO, included Ryan Kieda (K '09), Kelsey Breck (K '10), and Associate Professor Jeffrey Bartz as co-authors. She completed the work for the poster during Summer 2008 in Professor Bartz's lab.
[Western Spectroscopy 2009]Ryan Kieda (K '09) presented a poster at the 56th Annual Western Spectroscopy Association January 28 – 30, 2009, at the Asilomar Conference Center, Pacific Grove, CA. His poster, Vector Correlation in the 225-nm Photodissociation of Cobalt Tricarbonyl Nitrosyl, included Amber Peden (K '11), Kelsey Breck (K '10), and Associate Professor Jeffrey Bartz as co-authors. Ryan's poster described his Senior Individualized Project research in the Bartz lab in Summer 2008. He is currently a graduate student in physical chemistry at the University of Wisconsin-Madison.
Professor Thomas Smith was recently a coauthor on a communication in the Journal of the American Chemical Society*. The paper resulted from research involving scientists at the University of Pennsylvania Medical School, Stanford University Chemistry Department, Pfizer Inc., and Kalamazoo College. Two coauthors (DeGrado, Solomon) are members of the National Academy of Sciences. Smith set this collaboration in motion with Professor DeGrado (K '77) following his last sabbatical leave at MIT. The paper was his second publication in JACS in the previous four years.
*Oxygen Reactivity of the Biferrous Site in the de novo Designed Four Helix Bundle Peptide DFsc: Nature of the “Intermediate” and Reaction Mechanism. J. R. Calhoun, C. B. Bell, T. J. Smith, T. J. Thamann, J. D. Lear, W. F. DeGrado, E. I. Solomon, J. Am. Chem. Soc., 2008, 130, 9188–9189.
Dr. Smith contributed to a successful multi-institutional National Science Foundation grant, which is funded from 2007 to 2009 to support teaching and research applications of the Cambridge Structural Database. This software allows his Inorganic Chemistry course and research students to survey a collection of more than 450,000 crystal and molecular structures. Coupling the CSD access to regular use of experimental X–ray crystallography at Purdue University, Smith’s research students gain in-depth exposure to this powerful structure determination tool. This past year he directed the research of two SIP students, one in Chemistry (Emily Moreno K '09) and another in Physics (Scott Beck K '09); they were his 55th and 56th senior thesis students.